Where the extracellular fluid undercools then cells can continue to metabolise, albeit slowly, to temperatures below the vitrification temperature of free-living microbes. Where this fluid freezes, then the cells will dehydrate and vitrify in a manner analogous to free-living microbes. In multicellular organisms the cells are isolated from ice in the environment, and the major factor dictating how they respond to low temperature is the physical state of the extracellular fluid. It is only where extracellular ice is not present that cells can continue to metabolise below these temperatures, and water droplets in clouds provide an important example of such a habitat. The temperature range for intracellular vitrification makes this a process of fundamental ecological significance for free-living microbes. The high internal viscosity following vitrification means that diffusion of oxygen and metabolites is slowed to such an extent that cellular metabolism ceases. In contrast to intracellular freezing, vitrification does not result in death and cells may survive very low temperatures once vitrified. We present empirical evidence that free-living microbial cells cooling in the presence of external ice will undergo freeze-induced desiccation and a glass transition (vitrification) at a temperature between −10☌ and −26☌.
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Located in Gainesville, just a short drive away, are the world-famous Shands Teaching Hospital and the region’s Veteran’s Hospital. Medical professionals with specialties and expertise in all disciplines can be found locally. The medical community of Marion County is exceptional, offering four area hospitals, two of which are only minutes from On Top of the World. We’re also close to beaches on the East and West Coasts. Centrally located within the state, Ocala is close to major cities like Orlando, Daytona, Tampa, Jacksonville, and is minutes away from Gainesville, home to the University of Florida Gators. Outdoor recreation at state parks, dining at unique local restaurants, concerts and live theatre, antiquing in nearby historic towns, and so much more await you here.
It’s peaceful and laid back but with plenty of options to fill your days with fun. Sunny weather, tranquil landscapes and a low cost of living make Ocala an ideal place to call home. And the rest of the world is just outside its gates.Īlso topping the list of best retirement cities is Ocala. Florida tops the list of best states for retirement, and located at the center of Florida with its leisurely lifestyle, On Top of the World provides unsurpassed active adult living within this expansive community.